for a full publication list go to PubMed
Out with the old, in with the new: dendrite degeneration and regeneration. Hertzler, J. I., Rolls, M. M. (2024) in Wiring the nervous system: mechanisms of axonal and dendritic remodeling in health and disease. Eds. Tran, T. S., Yaron, A.
Ciliated sensory neurons can regenerate axons after complete axon removal. Stone, M. C., Mauger, A. S, (equal contributors), Rolls, M. M. (2023) Journal of Experimental Biology. 226: doi:10.1242/jeb.245717.
Dendrite regeneration mediates functional recovery after complete dendrite removal. Hertzler, J. I., Bernard, A. R., Rolls, M. M. (2023) Developmental Biology 497:18-25.
The exocyst complex is required for developmental and regenerative neurite growth in vivo. Swope, R. D., Hertzler, J. I., Stone, M. C., Kothe, G. O., Rolls, M. M. (2022) Developmental Biology 492:1-13.
The MAP3Ks DLK and LZK direct diverse responses to axon damage in zebrafish peripheral neurons. Adula, K., Shorey, M., Chauhan, V., Nassman, K., Chen, S.-F., Rolls, M. M., Sagasti, A. (2022) Journal of Neuroscience 42: 6195-6210.
Dendrite regeneration in the vertebrate spinal cord. Stone, M. C., Seebold, D. Y., Shorey, M., Kothe, G. O., Rolls, M. M. (2022) Developmental Biology 488: 114-119.
Microtubule polarity is instructive for many aspects of neuronal polarity. Thyagarajan, P., Feng, C., Lee, D., Shorey, M., Rolls, M. M. (2022) Developmental Biology 486:56-70.
Principles of microtubule polarity in linear cells. Rolls, M. M. (2022) Developmental Biology 483: 112-117.
Microtubule organization of vertebrate sensory neurons in vivo. Shorey, M., Rao, K., Stone, M. C., Mattie, F. J., Sagasti, A., Rolls, M. M. (2021) Developmental Biology 478:1-12.
Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules. Feng, C., Cleary, J. M., Kothe, G. O., Stone, M. C., Weiner, A. T., Hertzler, J. I., Hancock, W. O., Rolls, M. M. (2021) Journal of Cell Science 34(11):jcs258437.
To nucleate or not, that is the question in neurons. Weiner, A. T., Thyagarajan, P., Shen, Y., Rolls M. M. (2021) Neuroscience Letters 751:135806.
Cytoskeletal and synaptic polarity of LWamide-like+ ganglion neurons in the sea anemone Nematostella vectensis. Stone, M. C., Kothe, G. O., Rolls, M. M., Jegla, T. (2020) Journal of Experimental Biology 223:jeb233197.
Kinetochore proteins suppress neuronal microtubule dynamics and promote dendrite regeneration. Hertzler, J. I., Simonovitch, S. I., Albertson, R. M., Weiner, A. T., Nye, D. M. R., Rolls, M. M. (2020) Molecular Biology of the Cell 31: 2125-2138.
Neurons survive simultaneous injury to axons and dendrites and regrow both types of processes in vivo. Shorey, M., Stone, M. C., Mandel, J., Rolls, M. M. (2020) Developmental Biology 465:108-118.
Microtubule dynamics in healthy and injured neurons. Rolls, M. M., Thyagarajan, P., Feng, C. (2020) Developmental Neurobiology 10.1002/dneu22746.
Endosomal Wnt signaling proteins control microtubule nucleation in dendrites. Weiner, A. T., Seebold, D. Y., Torres-Gutierrez, P., Folker, C., Swope, R. D., Kothe, G. O., Stoltz, J. G., Zalenski, Kozlowski, K., Barbera, D. J., Patel, M. A., Thyagarajan, P., Shorey, M., Nye, D. M., Keegan, M., Behari, K., Song, S., Axelrod, J. D., Rolls, M. M. (2020) PLOS Biology 18(3):e3000647.
The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons. Nye, D. M. R., Albertson, R. M., Weiner, A. T., Hertzler, J. I., Shorey, M., Goberdhan, D. C. I, Wilson, C., Janes, K. A., Rolls, M. M. (2020) PLOS Biology 18(3):e3000657.
Patronin-mediated minus end growth is required for dendritic microtubule polarity. Feng, C., Thyagarajan, P., Shorey, M., Seebold, D. Y., Weiner, A. T., Albertson, R. M., Rao, K. S., Sagasti, A., Goetschius, D. J., Rolls, M. M. (2019) Journal of Cell Biology 218: 2309-2328.
Identification of proteins required for precise positioning of Apc2 in dendrites. Weiner, A. T., Seebold, D. Y., Michael, N. L., Guignet, M. L., Feng, C., Follick, B., Yusko, B. A., Wasilko, N. P., Torres-Gutierrez, P., Rolls, M. M. (2018) G3 8:1841-533.
Two Drosophila model neurons can regenerate axons from the stump or a converted dendrite, with feedback between the two sites. Rao, K. S., Rolls, M. M. (2017) Neural Development 12:15.
Mitochondria and caspases tune Nmnat-mediated stabilization to promote axon regeneration. Chen, L., Nye, D. M., Stone, M. C., Weiner, A. T., Gheres, K. W., Xiong, X., Collins, C. A., Rolls, M. M. (2016) PLOS Genetics 12:e1006503.
Bilaterian giant ankyrins have a common evolutionary origin and play a conserved role in the formation of a diffusion barrier at the axon initial segment. Jegla, T., Nguyen M.M., Feng, C., Goetschius, D.J., Luna, E., van Rossum, D.B., Kamel, B., Pisupati, A., Milner, E.S., Rolls, M.M. (2016) PLOS Genetics, 12:e1006457.
Spastin, atlastin and ER relocalization are involved in axon, but not dendrite, regeneration.
Rao K, Stone MC, Weiner AT, Gheres KW, Zhou C, Deitcher DL, Levitan ES, Rolls MM
Molecular Biology of the Cell. 2016 Sep 7 pii: mbc.E16-05-0287.
The microtubule severing protein fidgetin acts after dendrite injury to promote degeneration.
Tao J, Feng C, Rolls MM.
Journal of cell science. 2016 Jul 13
Kinesin-2 and Apc function at dendrite branch points to resolve microtubule collisions.
Weiner AT, Lanz MC, Goetschius DJ, Hancock WO, Rolls MM
Cytoskeleton (Hoboken). 2016 Jan;73(1):35-44. doi: 10.1002/cm.21270.
Neuronal polarity: an evolutionary perspective.
Rolls MM, Jegla TJ
J Exp Biol. 2015 Feb 15;218(Pt 4):572-80. doi: 10.1242/jeb.112359.
Γ-tubulin controls neuronal microtubule polarity independently of Golgi outposts.
Nguyen MM, McCracken CJ, Milner ES, Goetschius DJ, Weiner AT, Long MK, Michael NL, Munro S, Rolls MM.
Mol Biol Cell. 2014 Jul 1;25(13):2039-50. doi: 10.1091/mbc.E13-09-0515. Epub 2014 May 7.
An EB1-Kinesin Complex Is Sufficient to Steer Microtubule Growth In Vitro.
Chen Y, Rolls MM, Hancock WO
Curr Biol. 2014 Jan 21. pii: S0960-9822(13)01443-7. doi: 10.1016/j.cub.2013.11.024
Dendrite Injury Triggers DLK-Independent Regeneration.
Stone MC, Albertson RM, Chen L, Rolls MM.
Cell Rep. 2014 Jan 7. pii: S2211-1247(13)00767-5. doi: 10.1016/j.celrep.2013.12.022.
A postmitotic function and distinct localization mechanism for centralspindlin at a stable intercellular bridge.
Zhou K, Rolls MM, Hanna-Rose W.
Dev Biol. 2013 Apr 1;376(1):13-22. doi: 10.1016/j.ydbio.2013.01.020. Epub 2013 Jan 29.
Normal spastin gene dosage is specifically required for axon regeneration.
Stone MC, Rao K, Gheres KW, Kim S, Tao J, La Rochelle C, Folker CT, Sherwood NT, Rolls MM.
Cell Rep. 2012 Nov 29;2(5):1340-50. doi: 10.1016/j.celrep.2012.09.032. Epub 2012 Nov1
Development of dendrite polarity in Drosophila neurons.
Hill SE, Parmar M, Gheres KW, Guignet MA, Huang Y, Jackson FR, Rolls MM.
Neural Dev. 2012 Oct 30;7:34. doi: 10.1186/1749-8104-7-34.
Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila.
Stewart A, Tsubouchi A, Rolls MM, Tracey WD, Sherwood NT.
J Neurosci. 2012 Aug 22;32(34):11631-42. doi: 10.1523/JNEUROSCI.0729-12.2012.
Axon injury and stress trigger a microtubule-based neuroprotective pathway.
Chen L, Stone MC, Tao J, Rolls MM.
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11842-7. doi: 10.1073/pnas.1121180109. Epub 2012 Jun 25.
Microtubules are organized independently of the centrosome in Drosophila neurons.
Nguyen MM, Stone MC, Rolls MM.
Neural Dev. 2011 Dec 6;6:38. doi: 10.1186/1749-8104-6-38.
Neuronal polarity in Drosophila: sorting out axons and dendrites.
Rolls MM.
Dev Neurobiol. 2011 Jun;71(6):419-29. doi: 10.1002/dneu.20836. Review.
Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning.
Tao J, Rolls MM.
J Neurosci. 2011 Apr 6;31(14):5398-405. doi: 10.1523/JNEUROSCI.3826-10.2011.
Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites.
Mattie FJ, Stackpole MM, Stone MC, Clippard JR, Rudnick DA, Qiu Y, Tao J, Allender DL, Parmar M, Rolls MM.
Curr Biol. 2010 Dec 21;20(24):2169-77. doi: 10.1016/j.cub.2010.11.050. Epub 2010 Dec 9.
Global up-regulation of microtubule dynamics and polarity reversal during regeneration of an axon from a dendrite.
Stone MC, Nguyen MM, Tao J, Allender DL, Rolls MM.
Mol Biol Cell. 2010 Mar 1;21(5):767-77. doi: 10.1091/mbc.E09-11-0967. Epub 2010 Jan 6.
Microtubules have opposite orientation in axons and dendrites of Drosophila neurons.
Stone MC, Roegiers F, Rolls MM.
Mol Biol Cell. 2008 Oct;19(10):4122-9. doi: 10.1091/mbc.E07-10-1079. Epub 2008 Jul 30.
The Rolls Lab 